Abstract | BACKGROUND/AIMS: MATERIAL AND METHODS: Patients who presented with acute hepatitis between February 2001 and March 2009 were reevaluated for the etiology of liver disease. Patients with acute viral hepatitis, metabolic liver disease, vascular liver disease such as Budd-Chiari syndrome, biliary obstruction, or alcohol consumption were excluded. The autoimmune hepatitis scores, which were calculated at the time of diagnosis according to the criteria of the International Autoimmune Hepatitis Group, were recorded. In addition, the simplified criteria of the same group were applied retrospectively to each patient. Patients with ornidazole-induced toxic hepatitis with autoimmune hepatitis were included to constitute the study group of this report. All patients underwent initial liver biopsy, and one patient underwent liver biopsy three years later. All biopsies were scored according to the hepatitis scoring system by Ishak et al. (10). RESULTS: CONCLUSIONS:
Ornidazole may cause drug-induced autoimmune hepatitis. Withdrawal of the drug may not provide the recovery despite a rather long wait. Thus, immunosuppressive therapy may be suggested in these cases.
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Authors | Galip Ersöz, Rukiye Vardar, Ulus Salih Akarca, Fatih Tekın, Funda Yilmaz, Fulya Günşar, Zeki Karasu |
Journal | The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology
(Turk J Gastroenterol)
Vol. 22
Issue 5
Pg. 494-9
(Oct 2011)
ISSN: 2148-5607 [Electronic] Turkey |
PMID | 22234756
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Glucocorticoids
- Immunosuppressive Agents
- Ornidazole
- Prednisolone
- Azathioprine
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Topics |
- Adult
- Azathioprine
(administration & dosage)
- Biopsy
- Chemical and Drug Induced Liver Injury
(diagnosis, drug therapy, etiology)
- Drug Therapy, Combination
- Female
- Glucocorticoids
(administration & dosage)
- Hepatitis, Autoimmune
(diagnosis, drug therapy, etiology)
- Humans
- Immunosuppressive Agents
(administration & dosage)
- Middle Aged
- Ornidazole
(adverse effects)
- Prednisolone
(administration & dosage)
- Retrospective Studies
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