FADD expression as a prognosticator in early-stage glottic squamous cell carcinoma of the larynx treated primarily with radiotherapy.

Abstract

PURPOSE:

We recently reported on the identification of the Fas-associated death domain (FADD) as a possible driver of the chromosome 11q13 amplicon and the association between increased FADD expression and disease-specific survival in advanced-stage laryngeal carcinoma. The aim of this study was to examine whether expression of FADD and its Ser194-phosphorylated isoform (pFADD) predicts local control in patients with early-stage glottic carcinoma primarily treated with radiotherapy only.

METHODS AND MATERIALS:

Immunohistochemical staining for FADD and pFADD was performed on pretreatment biopsy specimens of 92 patients with T1-T2 glottic squamous cell carcinoma primarily treated with radiotherapy between 1996 and 2005. Cox regression analysis was used to correlate expression levels with local control.

RESULTS:

High levels of pFADD were associated with significantly better local control (hazard ratio, 2.40; 95% confidence interval, 1.04-5.55; p = 0.040). FADD overexpression showed a trend toward better local control (hazard ratio, 3.656; 95% confidence interval, 0.853-15.663; p = 0.081). Multivariate Cox regression analysis showed that high pFADD expression was the best predictor of local control after radiotherapy.

CONCLUSIONS:

This study showed that expression of phosphorylated FADD is a new prognostic biomarker for better local control after radiotherapy in patients with early-stage glottic carcinomas.

• Authors: Michiel L Schrijvers, Wouter J Pattje, Lorian Slagter-Menkema, Mirjam F Mastik, Johan H Gibcus, Johannes A Langendijk, Jacqueline E van der Wal, Bernard F A M van der Laan, E Schuuring
• Journal: International journal of radiation oncology, biology, physics (Int J Radiat Oncol Biol Phys) Vol. 83 Issue 4 Pg. 1220-6 (Jul 15 2012) ISSN: 1879-355X [Electronic] United States
• PMID: 22208968 (Publication Type: Journal Article)
• Copyright: Copyright © 2012 Elsevier Inc. All rights reserved.

Chemical References

• Biomarkers, Tumor
• Cortactin
• FADD protein, human
• Fas-Associated Death Domain Protein
• Neoplasm Proteins
• Protein Isoforms
• Cyclin D1

Topics

• Adult
• Aged
• Aged, 80 and over
• Biomarkers, Tumor (metabolism)
• Carcinoma, Squamous Cell (metabolism, mortality, pathology, radiotherapy)
• Cortactin (metabolism)
• Cyclin D1 (metabolism)
• Fas-Associated Death Domain Protein (metabolism)
• Female
• Glottis
• Humans
• Laryngeal Neoplasms (metabolism, mortality, pathology, radiotherapy)
• Male
• Middle Aged
• Neoplasm Proteins (metabolism)
• Neoplasm Recurrence, Local (metabolism)
• Prognosis
• Protein Isoforms (metabolism)