Peptidoglycan recognition proteins: modulators of the microbiome and inflammation.

Abstract

All animals, including humans, live in symbiotic association with microorganisms. The immune system accommodates host colonization by the microbiota, maintains microbiota-host homeostasis and defends against pathogens. This Review analyses how one family of antibacterial pattern recognition molecules - the peptidoglycan recognition proteins - has evolved a fascinating variety of mechanisms to control host interactions with mutualistic, commensal and parasitic microorganisms to benefit both invertebrate and vertebrate hosts.

• Authors: Julien Royet, Dipika Gupta, Roman Dziarski
• Journal: Nature reviews. Immunology (Nat Rev Immunol) Vol. 11 Issue 12 Pg. 837-51 (Nov 11 2011) ISSN: 1474-1741 [Electronic] England
• PMID: 22076558 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Antimicrobial Cationic Peptides
• Carrier Proteins
• Peptidoglycan
• peptidoglycan recognition protein

Topics

• Animal Structures (microbiology)
• Animals
• Antimicrobial Cationic Peptides (metabolism)
• Carrier Proteins (chemistry, immunology, physiology)
• Conserved Sequence
• Embryo, Nonmammalian (immunology, microbiology)
• Eukaryota (immunology)
• Homeostasis (immunology)
• Host-Parasite Interactions (immunology)
• Host-Pathogen Interactions (immunology)
• Humans
• Immunity, Innate
• Inflammation (immunology, metabolism)
• Intestines (microbiology)
• Invertebrates (immunology, microbiology)
• Metagenome (immunology)
• Models, Biological
• Models, Molecular
• Peptidoglycan (immunology, metabolism)
• Protein Conformation
• Protein Structure, Tertiary
• Structure-Activity Relationship
• Symbiosis (immunology)
• Vertebrates (immunology, microbiology)