Abstract | BACKGROUND:
Netrin-1 is a laminin-related secreted protein, is highly induced after tissue injury, and may serve as a marker of injury. However, the regulation of netrin-1 production is not unknown. Current study was carried out in mouse and mouse kidney cell line (TKPTS) to determine the signaling pathways that regulate netrin-1 production in response to injury. METHODS AND PRINCIPAL FINDINGS: CONCLUSION: Our results suggest that netrin-1 expression is suppressed at the translational level and MAPK activation leads to rapid translation of netrin-1 mRNA in the kidney tubular epithelial cells.
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Authors | Calpurnia Jayakumar, Riyaz Mohamed, Punithavathi Vilapakkam Ranganathan, Ganesan Ramesh |
Journal | PloS one
(PLoS One)
Vol. 6
Issue 10
Pg. e26776
( 2011)
ISSN: 1932-6203 [Electronic] United States |
PMID | 22046354
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
- Nerve Growth Factors
- Ntn1 protein, mouse
- Tumor Suppressor Proteins
- Netrin-1
- Mitogen-Activated Protein Kinases
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Topics |
- Animals
- Epithelial Cells
(metabolism)
- Kidney
(injuries, pathology)
- Kidney Tubules
(metabolism)
- Mice
- Mitogen-Activated Protein Kinases
(metabolism)
- Nerve Growth Factors
(biosynthesis, genetics, metabolism)
- Netrin-1
- RNA Stability
- Reperfusion Injury
- Signal Transduction
- Tumor Suppressor Proteins
(biosynthesis, genetics, metabolism)
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