Abstract | BACKGROUND: OBJECTIVE: METHODS: RESULTS: In Cox proportional hazards model multivariate analysis, digoxin use (Hazard Ratio=3.17; 95% Confidence Interval 1.62 to 6.18; p=0.001), need of inotropic support (Hazard Ratio=2.08; 95% Confidence Interval 1.43 to 3.02; p<0.005), left ventricular ejection fraction (Hazard Ratio=0.97; 95% Confidence Interval 0.95 to 0.99; p<0.005), and Chagas cardiomyopathy etiology (Hazard Ratio=3.29; 95% Confidence Interval 1.89 to 5.73; p<0.005) were positively associated with mortality, whereas beta-blocker therapy (Hazard Ratio=0.39; 95% Confidence Interval 0.26 to 0.56; p<0.005) was negatively associated with mortality. Survival probability for patients with Chagas cardiomyopathy at 8, 24, and 49 months was 83%, 61%, and 41%, respectively, and for patients with idiopathic dilated cardiomyopathy 97%, 92%, and 82%, respectively (p<0.005). CONCLUSION:
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Authors | Amanda Pires Barbosa, Augusto Cardinalli Neto, Ana Paula Otaviano, Bianca Faria Rocha, Reinaldo Bulgarelli Bestetti |
Journal | Arquivos brasileiros de cardiologia
(Arq Bras Cardiol)
Vol. 97
Issue 6
Pg. 517-25
(Dec 2011)
ISSN: 1678-4170 [Electronic] Brazil |
PMID | 22030565
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Adrenergic beta-Antagonists
- Digoxin
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Topics |
- Adrenergic beta-Antagonists
(adverse effects, therapeutic use)
- Cardiomyopathy, Dilated
(diagnostic imaging, drug therapy, mortality)
- Chagas Cardiomyopathy
(diagnostic imaging, drug therapy, mortality)
- Digoxin
(adverse effects, therapeutic use)
- Epidemiologic Methods
- Female
- Humans
- Male
- Middle Aged
- Prognosis
- Treatment Outcome
- Ultrasonography
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