Cinryze (C1-inhibitor) for the treatment of hereditary angioedema.

Abstract

Cinryze is a pasteurized, nanofiltered plasma derived concentrate of C1-inhibitor (pdC1-INH) licensed for the prophylactic treatment of hereditary angioedema. In a double-blind placebo-controlled crossover trial to evaluate Cinryze as prophylaxis, the frequency of attacks was halved (6.26 per 12 weeks on Cinryze versus 12.73 per 12 weeks on placebo). Furthermore, attacks were generally milder and of shorter duration. For treatment of acute attacks in patients receiving Cinryze, 1000 units, within 4 h of the start of an attack, the estimated time to the onset of unequivocal relief was reduced to 2 h, compared with more than 4 h in those treated with placebo. Cinryze and other similar products are going to change the future management of hereditary angioedema and have potential in other areas of medicine.

• Authors: Mark M Gompels, Robert John Lock
• Journal: Expert review of clinical immunology (Expert Rev Clin Immunol) Vol. 7 Issue 5 Pg. 569-73 (Sep 2011) ISSN: 1744-8409 [Electronic] England
• PMID: 21895469 (Publication Type: Journal Article, Review)

Chemical References

• Complement C1
• Complement C1 Inactivator Proteins
• Complement C1 Inhibitor Protein
• SERPING1 protein, human

Topics

• Angioedemas, Hereditary (prevention & control)
• Complement C1 (antagonists & inhibitors)
• Complement C1 Inactivator Proteins (therapeutic use)
• Complement C1 Inhibitor Protein
• Double-Blind Method
• Female
• Humans
• Male
• Randomized Controlled Trials as Topic
• Time Factors