The pathogenesis of Hodgkin's disease.

Abstract

Extensive clinical research over the past few decades has changed Hodgkin's disease from a routinely fatal disease to a usually curable disease. However, treatment is far from perfect; a substantial percentage of patients are not cured of their primary disease, and a substantial percentage of patients die of treatment-related second malignancies. Present efforts in clinical research are likely to result in improved antitumor therapy and a reduction in second malignancies; however, it is unrealistic to expect that they will result in striking improvements. Major new advances in Hodgkin's disease will require a better understanding of the biology of the disease.

• Authors: R H Collins Jr
• Journal: Blood reviews (Blood Rev) Vol. 4 Issue 1 Pg. 61-8 (Mar 1990) ISSN: 0268-960X [Print] England
• PMID: 2182148 (Publication Type: Journal Article, Review)

Chemical References

• Antigens, Differentiation
• Antigens, Neoplasm
• Biological Factors
• Biomarkers, Tumor
• Cytokines

Topics

• Antigens, Differentiation (analysis)
• Antigens, Neoplasm (analysis)
• Biological Factors (biosynthesis)
• Biomarkers, Tumor (analysis)
• Clone Cells (pathology)
• Cytokines
• Hodgkin Disease (etiology, genetics, microbiology, pathology)
• Humans
• Immunity, Cellular
• Immunologic Deficiency Syndromes (etiology)
• Models, Biological
• Neoplastic Stem Cells (pathology)
• Virus Diseases (complications)