Abstract | OBJECTIVES: METHODS: A total of 12 male Sprague-Dawley rats (350-400 g) were used in this study. Two groups (n = 6 per group) were generated as follows: sham operation and traumatic brain injury+1·0 mg/kg BQ-123 delivered intravenously 30 minutes prior to the injury. Trauma was induced using a weight acceleration impact device. Animals were terminated 24 or 48 hours after trauma, and a series of six coronal sections through the entire anterior-posterior extent of the corpus callosum were selected from each brain for quantification of diffuse axonal injury by beta-amyloid precursor protein immunostaining. RESULTS: Our data indicated that animals treated with BQ-123 30 minutes prior to trauma showed a significant reduction in diffuse axonal injury in corpus callosum at both 24 and 48 hours post-injury. CONCLUSION:
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Authors | Christian A Reynolds, Srinivasu Kallakuri, Mihir Bagchi, Steven Schafer, Christian W Kreipke, José A Rafols |
Journal | Neurological research
(Neurol Res)
Vol. 33
Issue 2
Pg. 192-6
(Mar 2011)
ISSN: 1743-1328 [Electronic] England |
PMID | 21801594
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
- Antihypertensive Agents
- Endothelin A Receptor Antagonists
- Endothelin-1
- Neuroprotective Agents
- Peptides, Cyclic
- Receptor, Endothelin A
- cyclo(Trp-Asp-Pro-Val-Leu)
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Topics |
- Animals
- Antihypertensive Agents
(administration & dosage)
- Axons
(drug effects, pathology, physiology)
- Brain Injuries
(drug therapy, metabolism, pathology)
- Diffuse Axonal Injury
(drug therapy, metabolism, pathology)
- Disease Models, Animal
- Endothelin A Receptor Antagonists
- Endothelin-1
(physiology)
- Injections, Intravenous
- Male
- Neuroprotective Agents
(pharmacology)
- Peptides, Cyclic
(administration & dosage)
- Rats
- Rats, Sprague-Dawley
- Receptor, Endothelin A
(physiology)
- Signal Transduction
(drug effects, physiology)
- Treatment Outcome
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