Histamine N-methyltransferase Thr105Ile polymorphism is associated with Parkinson's disease.

Abstract

Histamine is a central neurotransmitter degraded by histamine-N-methyltransferase (HNMT). Several abnormalities in the histaminergic system were found in patients with Parkinson's disease (PD), thus we tested the possible association of a Thr105Ile functional polymorphism in HNMT with PD. A total of 913 patients with PD and 958 controls were genotyped using a TaqMan RT-PCR Genotyping Assay (Foster City, California, USA). Lower frequency of HNMT Ile105 allele that is associated with decreased enzymatic activity was found in patients compared with controls (χ(2) = 11.65; p = 0.0006). We performed meta-analysis to confirm the association of Thr105Ile functional polymorphism with PD. Our results indicate that lower HNMT activity plays a role in the pathogenesis of PD.

• Authors: Vinko Palada, Janoš Terzić, Joseph Mazzulli, Grace Bwala, Johann Hagenah, Borut Peterlin, Albert Y Hung, Christine Klein, Dimitri Krainc
• Journal: Neurobiology of aging (Neurobiol Aging) Vol. 33 Issue 4 Pg. 836.e1-3 (Apr 2012) ISSN: 1558-1497 [Electronic] United States
• PMID: 21794955 (Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2012 Elsevier Inc. All rights reserved.

Chemical References

• Isoleucine
• Threonine
• Histamine N-Methyltransferase

Topics

• Asian People
• Case-Control Studies
• Chi-Square Distribution
• Female
• Gene Frequency
• Genetic Association Studies
• Genetic Predisposition to Disease (genetics)
• Genotype
• Histamine N-Methyltransferase (genetics)
• Humans
• Isoleucine (genetics)
• Male
• Meta-Analysis as Topic
• Parkinson Disease (genetics)
• Polymorphism, Single Nucleotide (genetics)
• Threonine (genetics)
• White People