Abstract | PURPOSE: PATIENTS AND METHODS: Sera from patients with polymyositis and sera found to contain anticytoplasmic antibodies were screened for antibody to PL-12 by testing for inhibition of ARS enzymatic activity by serum, and by immunoprecipitation. RESULTS: Nine sera inhibited ARS. These nine plus two additional sera with anticytoplasmic antibodies immunoprecipitated an identical pattern of tRNAs and a polypeptide of 110 kd. Of the 10 patients that could be evaluated, eight had some evidence of myositis, including six that satisfied the criteria for myositis. Three of these six, all with dermatomyositis, had severe muscle involvement. Eight of the 10 patients had radiographic evidence of pulmonary fibrosis, and seven of the eight had clinical pulmonary impairment, including four with clinically severe ILD. Joint manifestations were found in five patients, and arthritis was the only clinical problem in one patient. CONCLUSION: We conclude that anti-PL-12, like anti-Jo-1 and anti-PL-7, was frequently associated with the "Jo-1 syndrome" of myositis with ILD. ILD was a major clinical problem in this group of patients.
|
Authors | I N Targoff, F C Arnett |
Journal | The American journal of medicine
(Am J Med)
Vol. 88
Issue 3
Pg. 241-51
(Mar 1990)
ISSN: 0002-9343 [Print] United States |
PMID | 2178410
(Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)
|
Chemical References |
- Autoantibodies
- Amino Acyl-tRNA Synthetases
- Alanine-tRNA Ligase
|
Topics |
- Adult
- Alanine-tRNA Ligase
(immunology)
- Amino Acyl-tRNA Synthetases
(immunology)
- Autoantibodies
(immunology, isolation & purification)
- Female
- Humans
- Immunologic Techniques
- Male
- Middle Aged
- Myositis
(complications, immunology)
- Precipitin Tests
- Pulmonary Fibrosis
(complications, physiopathology)
- Respiratory Function Tests
|