Sertaconazole nitrate shows fungicidal and fungistatic activities against Trichophyton rubrum, Trichophyton mentagrophytes, and Epidermophyton floccosum, causative agents of tinea pedis.

Abstract

The fungistatic and fungicidal activities of sertaconazole against dermatophytes were evaluated by testing 150 clinical isolates of causative agents of tinea pedis, Trichophyton rubrum, Trichophyton mentagrophytes, and Epidermophyton floccosum. The overall geometric means for fungistatic and fungicidal activities of sertaconazole against these isolates were 0.26 and 2.26 μg/ml, respectively, although values were higher for T. mentagrophytes than for the others. This is the first comprehensive demonstration of the fungicidal activity of sertaconazole against dermatophytes.

• Authors: Alfonso J Carrillo-Muñoz, Cristina Tur-Tur, Delia C Cárdenes, Dolors Estivill, Gustavo Giusiano
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 55 Issue 9 Pg. 4420-1 (Sep 2011) ISSN: 1098-6596 [Electronic] United States
• PMID: 21746955 (Publication Type: Journal Article)

Chemical References

• Antifungal Agents
• Imidazoles
• Thiophenes
• sertaconazole

Topics

• Antifungal Agents (pharmacology)
• Epidermophyton (drug effects)
• Imidazoles (pharmacology)
• Microbial Sensitivity Tests
• Thiophenes (pharmacology)
• Tinea Pedis (microbiology)
• Trichophyton (drug effects)