A case of anti-GA1 antibody-positive Fisher syndrome with elevated tau protein in cerebrospinal fluid.

Abstract

We describe a boy with Fisher syndrome. He presented the typical symptoms of Fisher syndrome, including external ophthalmoplegia, abnormality of convergence, and areflexia, after an episode of Campylobacter enterocolitis. Atypically, however, anti-GA1 antibody was detected in his serum, though anti-GQ1b and anti-GT1a antibodies were not. In addition, the tau protein level in his cerebrospinal fluid was elevated. Generally, Fisher syndrome is a self-limiting disease and has a good prognosis. In our patient, however, mild diplopia and areflexia persisted 6 months after their onset. Here, we report on the first Fisher syndrome patient with anti-GA1 antibody in the serum and elevated tau protein in the cerebrospinal fluid.

• Authors: Yoshinobu Oyazato, Takashi Shiihara, Susumu Kusunoki, Masao Adachi, Noriko Ohnishi, Hiroaki Taniguchi, Atsushi Nishiyama, Aika Watanabe, Mitsuro Kobayashi, Ichiro Kamioka
• Journal: Brain & development (Brain Dev) Vol. 34 Issue 4 Pg. 329-32 (Apr 2012) ISSN: 1872-7131 [Electronic] Netherlands
• PMID: 21742448 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2011 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.

Chemical References

• Autoantibodies
• G(A1) ganglioside
• Gangliosides
• tau Proteins

Topics

• Autoantibodies (biosynthesis, blood)
• Autoimmune Diseases of the Nervous System (cerebrospinal fluid, immunology, microbiology)
• Campylobacter Infections (cerebrospinal fluid, immunology)
• Child
• Gangliosides (immunology)
• Humans
• Male
• Miller Fisher Syndrome (cerebrospinal fluid, immunology, microbiology)
• Up-Regulation (immunology)
• tau Proteins (biosynthesis, blood, cerebrospinal fluid)