Influence of dietary supplementation with Bacillus-fermented adlay on lipid metabolism, antioxidant status and intestinal microflora in hamsters.

Abstract

BACKGROUND:

The effects of polished and dehulled Bacillus-fermented adlay on lipid metabolism, antioxidant status and intestinal microflora were examined in hyperlipidaemic hamsters fed a high-cholesterol diet.

RESULTS:

Hamsters administered Bacillus-fermented adlay experienced significantly reduced (P < 0.05) serum and hepatic total cholesterol (by 37-43% and 42-49% respectively) and triglyceride (by 22-27% and 30-35% respectively) levels compared with the high-cholesterol group. Lower low-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratios in serum and increased cholesterol (by 47-52%) and triglyceride (by 40-47%) contents in faeces were also observed. Bacillus-fermented adlay lowered the levels of thiobarbituric acid-reactive substances, thus increasing total antioxidant and superoxide dismutase activities. In particular, polished Bacillus-fermented adlay had satisfactory antioxidant activity, similar to that of commercially available natto. Moreover, hamsters fed Bacillus-fermented adlay harboured greater populations of lactic acid bacteria, few coliforms and little Clostridium perfringens.

CONCLUSION:

This study has shown that changes in lipid metabolism, antioxidant status and intestinal microflora can be greatly modulated by Bacillus-fermented adlay, suggesting potential novel approaches to the treatment of primary cardiovascular and intestinal diseases.

• Authors: Chung-Yi Wang, Hsin-Tang Lin, She-Ching Wu
• Journal: Journal of the science of food and agriculture (J Sci Food Agric) Vol. 91 Issue 12 Pg. 2271-6 (Sep 2011) ISSN: 1097-0010 [Electronic] England
• PMID: 21618546 (Publication Type: Journal Article)
• Copyright: Copyright © 2011 Society of Chemical Industry.

Chemical References

• Antioxidants
• Lipids
• Superoxide Dismutase

Topics

• Animals
• Antioxidants (administration & dosage, metabolism)
• Bacillus subtilis (metabolism)
• Cecum (microbiology)
• Clostridium perfringens (isolation & purification)
• Coix (chemistry)
• Colony Count, Microbial
• Cricetinae
• Dietary Supplements
• Enterobacteriaceae (isolation & purification)
• Feces (chemistry, microbiology)
• Fermentation
• Hyperlipidemias (blood, metabolism, prevention & control)
• Lactobacillales (isolation & purification)
• Lipid Metabolism
• Lipids (blood)
• Liver (enzymology, metabolism)
• Male
• Mesocricetus
• Random Allocation
• Seeds (chemistry)
• Superoxide Dismutase (blood, metabolism)