Abstract |
The hypopigmenting agent monobenzone induces inflammatory responses only in pigmented skin as well as depigmentation in areas not directly exposed to the drug. Both observations have been ascribed to the possible induction of adaptive immune responses against melanocytes. In this issue, van den Boorn et al. provide direct evidence confirming this hypothesis. Since the monobenzone-induced immune responses target melanocyte- differentiation antigens, this report opens the opportunity for a simple and instantaneous deployable immunotherapy of melanoma.
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Authors | Jürgen C Becker, David Schrama |
Journal | The Journal of investigative dermatology
(J Invest Dermatol)
Vol. 131
Issue 6
Pg. 1185-7
(Jun 2011)
ISSN: 1523-1747 [Electronic] United States |
PMID | 21566576
(Publication Type: Comment, Journal Article)
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Chemical References |
- Hydroquinones
- monobenzone
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Topics |
- Adaptive Immunity
(drug effects)
- Cell Differentiation
- Humans
- Hydroquinones
(pharmacology, therapeutic use)
- Immune Tolerance
(drug effects)
- Immunotherapy
- Melanocytes
(cytology, drug effects, immunology)
- Melanoma
(therapy)
- Skin Pigmentation
(drug effects)
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