Abstract | OBJECTIVE: DATA SOURCES: MEDLINE/PubMed publication databases were searched for randomized, double-blind, placebo-controlled trials of antidepressants used as monotherapy for the acute-phase treatment of MDD and/or dysthymic disorder in patients with or without alcohol use disorders. The search term placebo was cross-referenced with each of the antidepressants approved by the US, Canadian, or European Union drug regulatory agencies for the treatment of MDD and/or dysthymic disorder. STUDY SELECTION: 195 articles were found eligible for inclusion in our analysis, 11 of which focused on the treatment of MDD/ dysthymic disorder in patients with comorbid alcohol use disorders. The search was limited to articles published between January 1, 1980, and March 15, 2009 (inclusive). RESULTS: CONCLUSIONS:
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Authors | Nadia Iovieno, Enrico Tedeschini, Kate H Bentley, A Eden Evins, George I Papakostas |
Journal | The Journal of clinical psychiatry
(J Clin Psychiatry)
Vol. 72
Issue 8
Pg. 1144-51
(Aug 2011)
ISSN: 1555-2101 [Electronic] United States |
PMID | 21536001
(Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't)
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Copyright | © Copyright 2011 Physicians Postgraduate Press, Inc. |
Chemical References |
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Topics |
- Alcoholism
(epidemiology, psychology, rehabilitation)
- Antidepressive Agents
(adverse effects, therapeutic use)
- Combined Modality Therapy
- Comorbidity
- Depressive Disorder, Major
(epidemiology, psychology, rehabilitation)
- Diagnosis, Dual (Psychiatry)
- Double-Blind Method
- Dysthymic Disorder
(epidemiology, psychology, rehabilitation)
- Evidence-Based Medicine
- Humans
- Psychotherapy
- Randomized Controlled Trials as Topic
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