Abstract | OBJECTIVES: Despite about 3 decades of clinical experience with the therapy of inherited thrombocytopathies (HTP) with desmopressin ( DDAVP) the mechanisms of haemostatic effects of DDAVP in these diseases remain unclear. Therefore platelet function diagnostics was carried out in whole blood (WB) from children with aspirin-like defect as one of the clinically mild forms of HTP after DDAVP administration. DESIGN AND METHODS: RESULTS: PA, ATP release and blood count were not influenced by DDAVP administration. PFA-100 CTs were markedly reduced at 120 and 240 min after DDAVP, respectively. FVIII:C, VWF:Ag and VWF:CB were increased after 120 min. CONCLUSION: The DDAVP-induced improvement of primary haemostasis in patients with aspirin-like defect is mainly due to the marked increase of the VWF. For the evaluation of the clinical effect of DDAVP administration in patients with aspirin-like defect the investigation of a larger group of patients is needed.
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Authors | J T Tauer, A Gneuss, J E Lohse, T Jürgens, R Knöfler |
Journal | Klinische Padiatrie
(Klin Padiatr)
Vol. 223
Issue 3
Pg. 169-72
(May 2011)
ISSN: 1439-3824 [Electronic] Germany |
PMID | 21509710
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © Georg Thieme Verlag KG Stuttgart · New York. |
Chemical References |
- Hemostatics
- Von Willebrand antigen
- von Willebrand Factor
- Adenosine Diphosphate
- Adenosine Triphosphate
- Thrombin
- Deamino Arginine Vasopressin
- Aspirin
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Topics |
- Adenosine Diphosphate
(blood)
- Adenosine Triphosphate
(blood)
- Adolescent
- Aspirin
(adverse effects)
- Blood Platelet Disorders
(blood, drug therapy, genetics)
- Blood Platelets
(drug effects)
- Child
- Child, Preschool
- Deamino Arginine Vasopressin
(administration & dosage)
- Female
- Hemostasis
(drug effects)
- Hemostatics
(administration & dosage)
- Humans
- Infusions, Intravenous
- Male
- Platelet Aggregation
(drug effects, genetics)
- Platelet Function Tests
- Thrombin
(metabolism)
- von Willebrand Factor
(immunology, metabolism)
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