[Effect on ocular blood flow of Combigan® versus placebo in patients with ocular hypertension].

Abstract

PURPOSE:

This study was undertaken to compare the ocular haemodynamic effects of Combigan(®) versus placebo in patients with ocular hypertension (OHT).

METHODS:

Thirty patients with OHT were included in a controlled, randomised, double blind study in two parallel groups; 15 were randomised to receive Combigan(®) and 15 to receive placebo for a period of 3 months. At baseline and at 3 months retrobulbar blood flowmeasurements of the ophthalmic artery (OA) and central retinal artery (CRA) were taken using colour Doppler imaging(CDI) ultrasound, concurrently with intraocular pressure (IOP).

RESULTS:

Combigan(®) significantly reduced IOP after 3 months of treatment (P = 0.001), whereas placebo showed no significant change in IOP. The baseline haemodynamic parameters were similar between treatment and placebo groups. Patients treated with Combigan® showed a statistically significant decrease in CRA resistive index (P = 0.007).

CONCLUSIONS:

Patients treated for 3 months with Combigan(®) showed a significant decrease of CRA resistive index that could be explained by the decrease in IOP.

• Authors: B Puerto-Hernández, G Rebolleda, J L García-Pérez, F J Muñoz-Negrete, C González-Gordaliza
• Journal: Archivos de la Sociedad Espanola de Oftalmologia (Arch Soc Esp Oftalmol) Vol. 86 Issue 2 Pg. 42-6 (Feb 2011) ISSN: 1989-7286 [Electronic] Spain
• Vernacular Title: Efecto de Combigan(®) versus placebo en el flujo sanguíneo ocular en pacientes hipertensos oculares.
• PMID: 21440829 (Publication Type: Comparative Study, English Abstract, Journal Article, Randomized Controlled Trial)
• Copyright: Copyright © 2011. Published by Elsevier Espana.

Chemical References

• Brimonidine Tartrate, Timolol Maleate Drug Combination
• Drug Combinations
• Ophthalmic Solutions
• Quinoxalines
• Timolol

Topics

• Aged
• Brimonidine Tartrate, Timolol Maleate Drug Combination
• Double-Blind Method
• Drug Combinations
• Female
• Follow-Up Studies
• Humans
• Intraocular Pressure (drug effects)
• Laser-Doppler Flowmetry
• Male
• Middle Aged
• Ocular Hypertension (drug therapy, physiopathology)
• Ophthalmic Artery (physiopathology)
• Ophthalmic Solutions
• Prospective Studies
• Quinoxalines (pharmacology, therapeutic use)
• Regional Blood Flow (drug effects)
• Retinal Vessels (physiopathology)
• Timolol (pharmacology, therapeutic use)
• Ultrasonography, Doppler, Color
• Vascular Resistance (drug effects)