Postnatal intravenous steroids and long-term neurological outcome: recommendations from meta-analyses.

Abstract

Postnatal steroids have been widely used to facilitate the extubation of ventilator-dependent preterm infants. Reports published in the late 1990s and early 2000s raised concerns about their long-term impact on neurodevelopmental outcomes. Since then, postnatal steroid use has declined sharply, but they continue to be regarded by many clinicians as an essential part of neonatal care, and there is considerable confusion as to the most appropriate time to use them. This review examines the meta-analyses of the relationship between intravenous postnatal steroids and neurodevelopmental impairment, and provides recommendations for their use based upon that body of evidence.

• Authors: H L Yates, S J Newell
• Journal: Archives of disease in childhood. Fetal and neonatal edition (Arch Dis Child Fetal Neonatal Ed) Vol. 97 Issue 4 Pg. F299-303 (Jul 2012) ISSN: 1468-2052 [Electronic] England
• PMID: 21427126 (Publication Type: Journal Article, Meta-Analysis)

Chemical References

• Glucocorticoids

Topics

• Cerebral Palsy (chemically induced)
• Chronic Disease
• Developmental Disabilities (chemically induced)
• Drug Administration Schedule
• Evidence-Based Medicine (methods)
• Glucocorticoids (administration & dosage, adverse effects, therapeutic use)
• Humans
• Infant, Newborn
• Infant, Premature
• Infant, Premature, Diseases (prevention & control)
• Injections, Intravenous
• Lung Diseases (prevention & control)
• Prognosis