Protective murine and human monoclonal antibodies against eczema vaccinatum.

Abstract

BACKGROUND:

Eczema vaccinatum is the most common severe pathology associated with smallpox vaccination (vaccinia virus), occurring at high rates among individuals with a previous history of atopic dermatitis (atopic eczema).

METHODS:

Monoclonal antibodies capable of neutralizing vaccinia virus, anti-H3 and anti-B5, were developed as a potential therapy for treatment of human eczema vaccinatum.

RESULTS:

Using a small animal model of eczema vaccinatum, we demonstrated that both murine and fully human monoclonal antibodies effectively limited eczema vaccinatum disease, foreshortening both the disease kinetics and the severity of the erosive viral skin lesions.

CONCLUSIONS:

These neutralizing antibodies would likely be effective at reducing or eliminating clinical disease in people with eczema vaccinatum or other severe side effects of the smallpox vaccine.

• Authors: Yoshiaki Tomimori, Yuko Kawakami, Megan M McCausland, Tomoaki Ando, Lilia Koriazova, Shinichiro Kato, Toshiaki Kawakami, Shane Crotty
• Journal: Antiviral therapy (Antivir Ther) Vol. 16 Issue 1 Pg. 67-75 ( 2011) ISSN: 2040-2058 [Electronic] England
• PMID: 21311110 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies, Monoclonal, Murine-Derived
• Antibodies, Neutralizing
• Protective Agents
• Smallpox Vaccine

Topics

• Animals
• Antibodies, Monoclonal, Murine-Derived (administration & dosage, immunology, therapeutic use)
• Antibodies, Neutralizing (administration & dosage, immunology, therapeutic use)
• Dermatitis, Atopic (complications, immunology)
• Disease Models, Animal
• Humans
• Kaposi Varicelliform Eruption (etiology, immunology, prevention & control, virology)
• Mice
• Mice, Inbred Strains
• Protective Agents (administration & dosage, therapeutic use)
• Smallpox (immunology, prevention & control)
• Smallpox Vaccine (administration & dosage, adverse effects)
• Vaccination (adverse effects)
• Vaccinia virus (immunology, pathogenicity)