An in vitro comparative study determining bactericidal activity of stabilized chlorine dioxide and other oral rinses.

Abstract

OBJECTIVE:

The study was conducted to determine the bactericidal activity of a stabilized chlorine dioxide oral rinse (ClōSYS Oral Rinse) compared to products currently available on the market.

METHODS:

Oral bacteria associated with gingivitis and periodontitis were exposed to rinses for one minute and five minutes. The numbers of colony forming units per milliliter (CFU/ml) were measured prior to and following exposure to determine the bactericidal activity.

RESULTS:

As expected, Listerine and Crest Pro-Health demonstrated complete kill on all bacteria exposed within one minute. Breath Rx exhibited the weakest levels of bactericidal effects overall. ClōSYS and chlorhexidine rinses proved identical 100% kills against the periodontal pathogens at five minutes; in some cases, ClōSYS oral rinse achieved a higher kill at the one-minute mark over the chlorhexidine rinse.

CONCLUSION:

The results demonstrated that ClōSYS Oral Rinse has potential for providing a therapeutic benefit, making it an attractive option to induce compliance in patients concerned about taste and tooth discoloration during oral health therapy.

• Authors: David Drake, Alissa L Villhauer
• Journal: The Journal of clinical dentistry (J Clin Dent) Vol. 22 Issue 1 Pg. 1-5 ( 2011) ISSN: 0895-8831 [Print] United States
• PMID: 21290979 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Bacterial Agents
• Anti-Infective Agents, Local
• Chlorine Compounds
• Crest Pro-Health mouthrinse
• Drug Combinations
• Mouthwashes
• Oxides
• Salicylates
• Terpenes
• Listerine
• chlorine dioxide
• Cetylpyridinium
• Chlorhexidine

Topics

• Actinomyces (classification, drug effects)
• Aggregatibacter actinomycetemcomitans (drug effects)
• Anti-Bacterial Agents (pharmacology)
• Anti-Infective Agents, Local (pharmacology)
• Bacterial Load
• Cetylpyridinium (pharmacology)
• Chlorhexidine (pharmacology)
• Chlorine Compounds (pharmacology)
• Drug Combinations
• Enterococcus faecalis (drug effects)
• Gingivitis (microbiology)
• Haemophilus influenzae (drug effects)
• Humans
• Klebsiella pneumoniae (drug effects)
• Materials Testing
• Mouthwashes (pharmacology)
• Oxides (pharmacology)
• Peptostreptococcus (drug effects)
• Periodontitis (microbiology)
• Porphyromonas gingivalis (drug effects)
• Prevotella nigrescens (drug effects)
• Pseudomonas aeruginosa (drug effects)
• Salicylates (pharmacology)
• Staphylococcus aureus (drug effects)
• Streptococcus (drug effects)
• Streptococcus mutans (drug effects)
• Streptococcus oralis (drug effects)
• Terpenes (pharmacology)
• Time Factors