Plasma isoflavones and the risk of lung cancer in women: a nested case-control study in Japan.

Abstract

BACKGROUND:

Although several epidemiologic studies have found that isoflavone intake assessed by questionnaire is associated with a decreased risk of lung cancer, no prospective study has investigated this association using blood concentrations of isoflavones.

METHODS:

We conducted a nested case-control study within a population-based prospective cohort study. A total of 24,127 women aged 40 to 69 years who returned the baseline questionnaire and provided blood samples were observed from 1990 through 2006. During a median follow-up period of 13.5 years, 126 newly diagnosed lung cancer cases were identified. For each case, we selected two controls matched for age, area, smoking status, and condition of blood draw. A conditional logistic regression model was used to estimate the odds ratios (ORs) and 95% CIs of lung cancer in relation to plasma concentrations of genistein, daidzein, glycitein, equol, and total isoflavones.

RESULTS:

After exclusion of 20 lung cancer cases diagnosed in the first 3 years after blood collection, an inverse association was found between plasma genistein concentration and lung cancer risk. The multivariate-adjusted OR (95% CI) of lung cancer in the highest quintile of plasma genistein concentration as compared with that in the lowest quintile was 0.31 (0.12, 0.86; P for trend=0.085). Other isoflavones and total isoflavones were not associated with a significant decrease in the risk of lung cancer.

CONCLUSION:

Plasma genistein concentration was inversely associated with lung cancer risk in Japanese women.

IMPACT:

Our data support the previously observed association between isoflavone intake and lung cancer risk.

• Authors: Taichi Shimazu, Manami Inoue, Shizuka Sasazuki, Motoki Iwasaki, Norie Sawada, Taiki Yamaji, Shoichiro Tsugane, JPHC Study Group
• Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology (Cancer Epidemiol Biomarkers Prev) Vol. 20 Issue 3 Pg. 419-27 (Mar 2011) ISSN: 1538-7755 [Electronic] United States
• PMID: 21239686 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: ©2011 AACR.

Chemical References

• Isoflavones
• Genistein

Topics

• Adult
• Aged
• Case-Control Studies
• Cohort Studies
• Female
• Genistein (blood)
• Humans
• Isoflavones (blood)
• Japan (epidemiology)
• Lung Neoplasms (blood)
• Middle Aged
• Prospective Studies
• Risk Factors