Abstract |
This study assesses whether administration of recombinant tissue-type plasminogen activator (rt-PA) up to 8 hours after onset of symptoms of acute myocardial infarction (AMI) may result in a significant improvement in left ventricular function. Sixty patients were classified into 3 groups: group A (n = 21) received rt-PA within 4 hours from symptom onset; the remaining 39 patients, admitted between 4 and 8 hours, were randomized into 2 groups--group B (n = 19) received rt-PA, and group C (n = 21) was treated with conventional therapy. Coronary and left ventricular angiograms were recorded 8 to 10 days after rt-PA administration. The patency rate of the infarct-related artery was 76% in group A, and 63 and 35% in group B and C, respectively. The Thrombolysis in Myocardial Infarction trial perfusion grade was higher in group A and B than in group C (A vs C: p less than 0.005; B vs C: p less than 0.01). Left ventricular ejection fraction was significantly higher in group A (60.2 +/- 10%) and B (54.7 +/- 12%) compared with group C (44.2 +/- 12%) (A vs C: p less than 0.01; B vs C: p less than 0.05). Regional wall motion of the entire ischemic zone was better in group A and B than in group C (A vs C: p less than 0.001; B vs C: p less than 0.01). In contrast, the kinesis of the central ischemic zone was significantly better in group A than in both group B and C (A vs B: p less than 0.05; A vs C: p less than 0.001).(ABSTRACT TRUNCATED AT 250 WORDS)
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Authors | B Villari, F Piscione, D Bonaduce, P Golino, T Lanzillo, M Condorelli, M Chiariello |
Journal | The American journal of cardiology
(Am J Cardiol)
Vol. 66
Issue 19
Pg. 1281-6
(Dec 01 1990)
ISSN: 0002-9149 [Print] United States |
PMID | 2123072
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Recombinant Proteins
- Tissue Plasminogen Activator
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Topics |
- Coronary Angiography
- Hemodynamics
(drug effects)
- Humans
- Middle Aged
- Myocardial Infarction
(drug therapy, physiopathology)
- Recombinant Proteins
(therapeutic use)
- Stroke Volume
(drug effects)
- Thrombolytic Therapy
- Tissue Plasminogen Activator
(therapeutic use)
- Vascular Patency
(drug effects)
- Ventricular Function, Left
(drug effects, physiology)
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