Successful management of gastrointestinal pythiosis in a dog using itraconazole, terbinafine, and mefenoxam.

Abstract

Medical therapy for pythiosis is hampered by a lack of efficacious drugs. The present report describes a case of canine gastrointestinal pythiosis in which lesions were resolved through the administration of itraconazole, terbinafine, and the agricultural fungicide mefenoxam. No substantial adverse effects occurred in association with administration of the latter compound. Additional studies are needed to evaluate the pharmacokinetics of mefenoxam and to further assess its tolerability and potential efficacy for the treatment of pythiosis in dogs.

• Authors: James Hummel, Amy Grooters, Gigi Davidson, Samuel Jennings, Jodi Nicklas, Adam Birkenheuer
• Journal: Medical mycology (Med Mycol) Vol. 49 Issue 5 Pg. 539-42 (Jul 2011) ISSN: 1460-2709 [Electronic] England
• PMID: 21174493 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antifungal Agents
• Naphthalenes
• Itraconazole
• mefenoxam
• Terbinafine
• Alanine

Topics

• Alanine (administration & dosage, adverse effects, analogs & derivatives)
• Animals
• Antifungal Agents (administration & dosage, adverse effects)
• Dog Diseases (diagnosis, drug therapy)
• Dogs
• Duodenum (pathology)
• Female
• Gastrointestinal Diseases (diagnosis, drug therapy, pathology, veterinary)
• Histocytochemistry
• Itraconazole (administration & dosage, adverse effects)
• Naphthalenes (administration & dosage, adverse effects)
• Pythiosis (diagnosis, drug therapy, pathology, veterinary)
• Pythium (isolation & purification)
• Terbinafine
• Treatment Outcome