Abstract | INTRODUCTION: AIM: METHODS: Sixteen male patients with IHH (mean age 27.5 ± 10.5 years, range 17-48 years) and 16 individually age-matched healthy men were included in the study. Human chorionic gonadotropin (HCG) was administered 1,500 U intramuscularly three times/week for 6 months, and then 75 U twice/week, recombinant follicle stimulating hormone (FSH) was added to HCG for the following 6 months. Polysomnography (PSG) recordings were performed at baseline in all and following the GnRT in the patient group. MAIN OUTCOME MEASURES: Sleep stages and sleep-breathing parameters on PSG. RESULTS: Patients with IHH had a higher percentage of slow-wave-sleep (SWS) (22.3 ± 6.3%) compared to that in the healthy controls (14.5 ± 9.5%; P = 0.009). Four patients and one control subject had OSA ( Apnea-Hypopnea Index [AHI] > 5(-h) ) at baseline (not significant). Following the GnRT in the patient group, there was a slight decrease in SWS (18.6 ± 6.4%; P = 0.05) without any significant changes regarding the sleep-breathing parameters in the whole patient group. However, of the four patients with OSA at baseline, the GnRT was associated with worsening of the AHI in three of them. CONCLUSIONS: IHH in men is associated with a higher percentage of SWS. One-year GnRT slightly decreases SWS and does not induce OSA. However, in patients with OSA at baseline long-term GnRT should be exercised with caution.
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Authors | Sevda Ismailogullari, Cuma Korkmaz, Yüksel Peker, Fahri Bayram, Züleyha Karaca, Murat Aksu |
Journal | The journal of sexual medicine
(J Sex Med)
Vol. 8
Issue 7
Pg. 2090-7
(Jul 2011)
ISSN: 1743-6109 [Electronic] Netherlands |
PMID | 21143417
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2010 International Society for Sexual Medicine. |
Chemical References |
- Chorionic Gonadotropin
- Hormones
- Follicle Stimulating Hormone
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Topics |
- Adolescent
- Adult
- Chorionic Gonadotropin
(adverse effects)
- Follicle Stimulating Hormone
(adverse effects)
- Hormone Replacement Therapy
(adverse effects)
- Hormones
(adverse effects)
- Humans
- Hypogonadism
(drug therapy)
- Male
- Middle Aged
- Polysomnography
- Sleep
(drug effects)
- Sleep Apnea, Obstructive
(chemically induced, diagnosis)
- Young Adult
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