[Clinical and cranial MRI analysis on five cases of toxic encephalopathy induced by dichloroethane].

Abstract

OBJECTIVE:

To investigate the clinical features, cranial MRI and treatment of toxic encephalopathy induced by 1, 2-dichloroethane (1, 2-DCE).

METHODS:

The clinical, MRI features and treatment of 5 patients with toxic encephalopathy induced by 1,2-DCE were observed and analyzed.

RESULTS:

Five patients all presented with subacute onset with a history of direct exposure to 1,2-DCE. Lumbar cerebrospinal fluid pressures were all increased in 5 patients. All 5 patients had obvious intracranial hypertension. Liver and kidney function had no obvious abnormalities; Cranial MRI showed T1WI low signal and T2WI high signal in bilateral hemispheric white matter, cerebellar dentate nucleus and globus pallidus. After the treatment of dehydrating agent, glucocorticoid and supportive treatment, four patients were clearly improved, and one patient had cerebral hernia formation.

CONCLUSION:

The main neurological clinical features in patients with 1,2-DEC poisoning is obvious intracranial hypertension. The prognosis is usually good with early and long term use of glucocorticoids and dehydrating agent in poisoning patients.

• Authors: Xiao-bo Yang, Hai-tao Hu, Yan Zhang, Shui-jiang Song
• Journal: Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases (Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi) Vol. 27 Issue 12 Pg. 744-6 (Dec 2009) ISSN: 1001-9391 [Print] China
• PMID: 21141135 (Publication Type: English Abstract, Journal Article)

Chemical References

• Ethylene Dichlorides

Topics

• Adult
• Ethylene Dichlorides (poisoning)
• Female
• Humans
• Magnetic Resonance Imaging
• Male
• Neurotoxicity Syndromes (diagnosis, therapy)
• Young Adult