Schwann cell abnormalities in 2,5-hexanedione neuropathy.

Abstract

Distinctive cytoplasmic alterations of Schwann cells were observed by electron microscopy in rats and mice with peripheral neuropathy induced by chronic exposure to 2,5-hexanedione. Pronounced enlargement of Schwann cells was due to accumulation of 100 angstrom cytoplasmic filaments and endoplasmic reticulum and was most often observed after 12--15 weeks exposure to 2,5-hexanedione. Examination of teased nerve fibres revealed segmental demyelination and remyelination involving axons of normal diameter as well as giant axons. The filament disorder induced by 2,5-hexanedione administration is not limited solely to axoplasmic contents. Possible mechanisms of demyelination are discussed and the changes are compared to those observed in human neuropathy for which 2,5-hexanedione appears to be the closest experimental model.

• Authors: H C Powell, T Koch, R Garrett, P W Lampert
• Journal: Journal of neurocytology (J Neurocytol) Vol. 7 Issue 4 Pg. 517-28 (Aug 1978) ISSN: 0300-4864 [Print] United States
• PMID: 211206 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Hexanones
• Ketones

Topics

• Animals
• Chronic Disease
• Demyelinating Diseases (chemically induced, pathology)
• Ganglia, Spinal (ultrastructure)
• Hexanones
• Ketones
• Mice
• Microscopy, Electron
• Nerve Degeneration
• Neurofibrils (ultrastructure)
• Peripheral Nervous System Diseases (chemically induced, pathology)
• Rats
• Schwann Cells (ultrastructure)
• Spinal Cord (ultrastructure)