Abstract | PURPOSE: METHODS: Nine patients with moderate AD, eight patients with MCI and seven age-matched healthy controls underwent 2-[(18)F]fluoro-3-(2(S)-azetidinylmethoxy) pyridine (2-[(18)F]FA-85380) PET. After coregistration with individual magnetic resonance imaging the binding potential (BP(ND)) of 2-[(18)F]FA-85380 was calculated using either the corpus callosum or the cerebellum as reference regions. PET data were analysed by region of interest analysis and by voxel-based analysis. RESULTS: Both patients with AD and MCI showed a significant reduction in 2-[(18)F]FA-85380 BP(ND) in typical AD-affected brain regions. Thereby, the corpus callosum was identified as the most suitable reference region. The 2-[(18)F]FA-85380 BP(ND) correlated with the severity of cognitive impairment. Only MCI patients that converted to AD in the later course (n = 5) had a reduction in 2-[(18)F]FA-85380 BP(ND). CONCLUSION: 2-[(18)F]FA-85380 PET appears to be a sensitive and feasible tool for the detection of a reduction in α4β2* nAChRs which seems to be an early event in AD. In addition, 2-[(18)F]FA-85380 PET might give prognostic information about a conversion from MCI to AD.
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Authors | Kai Kendziorra, Henrike Wolf, Philipp Mael Meyer, Henryk Barthel, Swen Hesse, Georg Alexander Becker, Julia Luthardt, Andreas Schildan, Marianne Patt, Dietlind Sorger, Anita Seese, Herman-Josef Gertz, Osama Sabri |
Journal | European journal of nuclear medicine and molecular imaging
(Eur J Nucl Med Mol Imaging)
Vol. 38
Issue 3
Pg. 515-25
(Mar 2011)
ISSN: 1619-7089 [Electronic] Germany |
PMID | 21069319
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- 2-fluoro-3-(2-azetidinylmethoxy)pyridine
- Azetidines
- Blood Proteins
- Pyridines
- Receptors, Nicotinic
- nicotinic receptor alpha4beta2
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Topics |
- Alzheimer Disease
(complications, diagnostic imaging, metabolism, pathology)
- Amnesia
(complications, diagnostic imaging, metabolism, pathology)
- Azetidines
(metabolism)
- Blood Proteins
(metabolism)
- Brain
(diagnostic imaging, metabolism)
- Case-Control Studies
- Female
- Humans
- Male
- Middle Aged
- Positron-Emission Tomography
- Pyridines
(metabolism)
- Receptors, Nicotinic
(metabolism)
- Software
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