Abstract |
Recent evidence suggests that a variety of environmental factors, including dietary and gastrointestinal agents, may contribute to autism spectrum disorders (ASD). Here we administered propionic acid (PPA), a short chain fatty acid that is used as a food preservative and also is a metabolic end-product of enteric bacteria in the gut, to adolescent (41 ± 4 days) male rats in a study of restricted/repetitive behavior, social behavior, and cognition. The goal was to further evaluate the effects of PPA in young rodents. PPA (4 μl of 0.26 M solution) was administered intracerebroventricularly prior to each behavioral test. Rats treated with PPA displayed restricted behavioral interest to a specific object among a group of objects, impaired social behavior, and impaired reversal in a T-maze task compared to controls given phosphate buffered saline. Immunohistochemical analysis of brain tissue from PPA rats revealed reactive astrogliosis and activated microglia, indicating an innate neuroinflammatory response. These findings are consistent with our earlier findings of ASD-relevant behavioral and brain events in adult rats given PPA, and support further study of effects of PPA in young rodents by establishing similar effects in adolescent animals.
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Authors | Derrick F MacFabe, Nathan E Cain, Francis Boon, Klaus-Peter Ossenkopp, Donald P Cain |
Journal | Behavioural brain research
(Behav Brain Res)
Vol. 217
Issue 1
Pg. 47-54
(Feb 02 2011)
ISSN: 1872-7549 [Electronic] Netherlands |
PMID | 20937326
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2010 Elsevier B.V. All rights reserved. |
Chemical References |
- Fatty Acids, Volatile
- Propionates
- propionic acid
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Topics |
- Animals
- Astrocytes
(drug effects, immunology)
- Child
- Child Development Disorders, Pervasive
(etiology)
- Cognition
(drug effects)
- Disease Models, Animal
- Exploratory Behavior
(drug effects)
- Fatty Acids, Volatile
(administration & dosage, pharmacology)
- Hippocampus
(drug effects, immunology)
- Humans
- Inflammation
(chemically induced)
- Injections, Intraventricular
- Maze Learning
(drug effects)
- Microglia
(drug effects, immunology)
- Propionates
(administration & dosage, pharmacology)
- Rats
- Rats, Long-Evans
- Social Behavior
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