[Combined cycloferon treatment of tuberculosis in patients infected with HIV].

Abstract

Outcome of treatment of 102 patients co-infected with HIV and tuberculosis hospitalized at Second Municipal Tuberculosis Hospital (St. Petersburg) is analyzed. The median period of follow up was 8 weeks. In order to select the optimum treatment scheme, all patients were divided into three groups (I-III). Group I (51 patients) received, in addition to antituberculosis medications, cycloferon 600 mg tablets on alternate days. Group II (16 patients) received alpha and gamma interferons (Interal injection, 3 MU and Ingaron injection, 500,000 on alternate days) in combination with antituberculosis medications. Control group III (35 patients) received antituberculosis treatment plus placebo. Assessment of the outcome of TB treatment upon 8 weeks of follow up showed a remarkable improvement of clinical and immunological conditions in the patients who received interferons and cycloferon.

• Authors: A K Ivanov, T V Sologub, A M Panteleev, D S Sukhanov, M G Romantsov, A L Kovalenko
• Journal: Eksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) Vol. 73 Issue 7 Pg. 32-5 (Jul 2010) ISSN: 0869-2092 [Print] Russia (Federation)
• PMID: 20821978 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Acridines
• Interferon Inducers
• Interferon-alpha
• Interferon-gamma
• 10-carboxymethyl-9-acridanone

Topics

• Acridines (therapeutic use)
• Adolescent
• Adult
• Female
• HIV Infections (complications, drug therapy, immunology)
• Humans
• Immunity, Cellular (drug effects)
• Interferon Inducers (therapeutic use)
• Interferon-alpha (therapeutic use)
• Interferon-gamma (therapeutic use)
• Male
• Middle Aged
• Tuberculosis, Pulmonary (complications, drug therapy, immunology)
• Young Adult