Progress in the development of therapeutic antibodies targeting prion proteins and beta-amyloid peptides.

Abstract

Prion diseases and Alzheimer's disease (AD) are characterized by protein misfolding, and can lead to dementia. However, prion diseases are infectious and transmissible, while AD is not. The similarities and differences between these diseases have led researchers to perform comparative studies. In the last 2 decades, progress has been made in immunotherapy using anti-prion protein and anti-beta-amyloid antibodies. In this study, we review new ideas and strategies for therapeutic antibodies targeting prion diseases and AD through conformation dependence.

• Authors: JinSheng He, Ying Zhang, Tao Hong
• Journal: Science China. Life sciences (Sci China Life Sci) Vol. 53 Issue 8 Pg. 959-63 (Aug 2010) ISSN: 1869-1889 [Electronic] China
• PMID: 20821294 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Amyloid beta-Peptides
• Antibodies
• Prions

Topics

• Amyloid beta-Peptides (immunology)
• Antibodies (immunology)
• Humans
• Prions (immunology)