| Abstract |
Herein we report that Aβ aggregates, not Aβ monomer, can convert Z-DNA back to B-form, and curcumin, a well-known Aβ aggregation inhibitor, can stop DNA Z-B transition studied by means of biophysical and biochemical methods. |
| Authors | Jie Geng, Chuanqi Zhao, Jinsong Ren, Xiaogang Qu |
| Journal | Chemical communications (Cambridge, England)
(Chem Commun (Camb))
Vol. 46
Issue 38
Pg. 7187-9
(Oct 14 2010)
ISSN: 1364-548X [Electronic] England |
| PMID | 20820525
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
| Chemical References |
- Amyloid beta-Peptides
- DNA, Z-Form
- Enzyme Inhibitors
- Curcumin
|
| Topics |
- Alzheimer Disease
(metabolism)
- Amyloid beta-Peptides
(metabolism)
- Curcumin
(pharmacology)
- DNA, Z-Form
(metabolism)
- Enzyme Inhibitors
(pharmacology)
- Humans
- Models, Molecular
- Protein Multimerization
|
