Interrelationship between oxygen-related variables in patients with acute myocardial infarction: an interpretative review.

Abstract

The high mortality rate of cardiogenic shock in acute myocardial infarction (AMI) implies that debate over the correct haemodynamic management is still unresolved. The purpose of this review is to re-evaluate the reciprocal relationships between oxygen-related variables and response to treatment in a large number of patients with AMI. A MEDLINE search of reports published between 1970 and 2008 was performed. Twelve clinical reports including 453 patients with AMI and 989 sets of oxygen delivery and oxygen consumption expressed in ml min⁻¹ m⁻² and oxygen extraction ratio were selected. While processing this data, we found an early down-regulation in oxygen demand linked to a decrease in oxygen supply. This mechanism is also supported in some studies by a critically low oxygen uptake that was not associated with lactic acidosis.

• Authors: Miguel A Jorge, Margarita Tavella, Célica L Irrazábal, Jorge G Peralta, Abelardo A Capdevila
• Journal: Clinical physiology and functional imaging (Clin Physiol Funct Imaging) Vol. 30 Issue 6 Pg. 381-8 (Nov 2010) ISSN: 1475-097X [Electronic] England
• PMID: 20726996 (Publication Type: Journal Article, Review)
• Copyright: © 2010 The Authors. Clinical Physiology and Functional Imaging © 2010 Scandinavian Society of Clinical Physiology and Nuclear Medicine.

Chemical References

• Oxygen

Topics

• Adaptation, Physiological
• Aged
• Aged, 80 and over
• Hemodynamics
• Humans
• Middle Aged
• Myocardial Infarction (complications, metabolism, physiopathology, therapy)
• Myocardium (metabolism)
• Oxygen (metabolism)
• Oxygen Consumption
• Oxygen Inhalation Therapy
• Shock, Cardiogenic (etiology, metabolism, physiopathology, therapy)