Abstract | PURPOSE: METHODS: A database of deidentified electronic medical records from hospitals and hospital-affiliated outpatient facilities throughout the United States was analyzed for PCI patients with or without a diagnosis of acute coronary syndrome (ACS) who received clopidogrel loading doses of > or =300 mg between 48 hours before and 6 hours after PCI. A high dose was defined as > or =600 mg, and pretreatment was defined as more than 6 hours before PCI for 300-599 mg and 2 or more hours before PCI for > or =600 mg. RESULTS: Among 6253 PCI patients who met the criteria, there were 2331 with a diagnosis of ACS (ACS-PCI) and 3922 without an ACS diagnosis (elective PCI). Of the ACS-PCI patients, 1359 had ST-segment elevation myocardial infarction ( STEMI) and 972 had unstable angina (UA) or non- ST-segment elevation myocardial infarction ( NSTEMI). A majority of ACS-PCI patients (57%) received a > or =600-mg loading dose, 34% received a 300-mg loading dose, and the rest received a loading dose between 300 and 600 mg. Loading consisted of a single bolus in 75% of patients, two doses in 21.5%, and three or more doses in 3.1%. The first dose was during or after PCI in 56% of the UA/ NSTEMI group and in 71% of both the elective PCI and STEMI groups. Among the UA/ NSTEMI group, only 33% met criteria for pretreatment. CONCLUSION: Reported practice patterns of clopidogrel administration before PCI for UA/ NSTEMI were not consistent with evidence generated from published clinical trials and guidelines. Recommended pre-treatment with clopidogrel was frequently not practiced.
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Authors | Bonnie B Dean, Hsing-Ting Yu, Jay P Bae, Suzanne Fiske, Eric Meadows, Yan Xiong, Matthew F Emons |
Journal | American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists
(Am J Health Syst Pharm)
Vol. 67
Issue 17
Pg. 1430-7
(Sep 01 2010)
ISSN: 1535-2900 [Electronic] England |
PMID | 20720242
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Platelet Aggregation Inhibitors
- Clopidogrel
- Ticlopidine
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Topics |
- Acute Coronary Syndrome
(drug therapy)
- Adult
- Aged
- Aged, 80 and over
- Angina Pectoris
(drug therapy)
- Angioplasty, Balloon, Coronary
- Clopidogrel
- Drug Utilization
- Electronic Health Records
- Female
- Hospitalization
- Humans
- Male
- Middle Aged
- Myocardial Infarction
(drug therapy)
- Perioperative Period
- Platelet Aggregation Inhibitors
(administration & dosage, therapeutic use)
- Practice Guidelines as Topic
- Retrospective Studies
- Ticlopidine
(administration & dosage, analogs & derivatives, therapeutic use)
- United States
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