Abstract | PURPOSE OF REVIEW: Although many advances have been made in the treatment of lymphoma in the past decade, the treatment of patients with relapsed and refractory disease remains challenging. Only a fraction of patients will be cured with salvage therapy and transplantation. For those patients that are either ineligible or relapse after transplant, the treatment options are limited. This illustrates the need for new drugs and novel treatment strategies. This review will focus on the emerging role of histone deacetylase inhibitors (HDACis) in patients with relapsed lymphoma. RECENT FINDINGS: SUMMARY: With the limited options available for lymphoma patients in the relapsed and refractory setting, the efficacy demonstrated by HDACis in this patient population is exciting and much needed and will hopefully prompt further investigation into additional agents and into the combination with HDACis.
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Authors | Amanda Copeland, Daniela Buglio, Anas Younes |
Journal | Current opinion in oncology
(Curr Opin Oncol)
Vol. 22
Issue 5
Pg. 431-6
(Sep 2010)
ISSN: 1531-703X [Electronic] United States |
PMID | 20683267
(Publication Type: Journal Article, Review)
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Chemical References |
- Histone Deacetylase Inhibitors
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Topics |
- Clinical Trials as Topic
- Histone Deacetylase Inhibitors
(therapeutic use)
- Humans
- Lymphoma
(drug therapy)
- Prognosis
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