Abstract | AIMS: METHODS: A total of 23 drug-naïve patients with major depressive disorder were genotyped and brain imaged with ([123I]) nor-beta-CIT single photon emission computed tomography. The severity of depression was evaluated with the 17-item Hamilton depression rating scale. RESULTS: Depressed patients homozygous for the short allele had lower ([123I]) nor-beta-CIT binding in the medial prefrontal cortex, but not in the midbrain, compared with the other genotypes. CONCLUSION: The decreased medial prefrontal cortical serotonin transporter binding in the patients homozygous for the short allele may be linked to altered function of the serotonin-transporter-linked polymorphic region gene expressed in these patients, especially in the medial prefrontal cortex.
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Authors | Mikko Joensuu, Soili Marianne Lehto, Tommi Tolmunen, Pirjo Irmeli Saarinen, Minna Valkonen-Korhonen, Ritva Vanninen, Pasi Ahola, Jari Tiihonen, Jyrki Kuikka, Ullamari Pesonen, Johannes Lehtonen |
Journal | Psychiatry and clinical neurosciences
(Psychiatry Clin Neurosci)
Vol. 64
Issue 4
Pg. 387-93
(Aug 2010)
ISSN: 1440-1819 [Electronic] Australia |
PMID | 20653909
(Publication Type: Journal Article)
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Chemical References |
- SLC6A4 protein, human
- Serotonin Plasma Membrane Transport Proteins
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Topics |
- Adult
- Alleles
- Brain
(pathology)
- Depressive Disorder, Major
(genetics, metabolism, pathology)
- Female
- Genotype
- Homozygote
- Humans
- Male
- Mesencephalon
(metabolism, pathology)
- Polymorphism, Genetic
(genetics)
- Prefrontal Cortex
(metabolism, pathology)
- Promoter Regions, Genetic
(genetics)
- Psychiatric Status Rating Scales
- Serotonin Plasma Membrane Transport Proteins
(genetics, metabolism)
- Tomography, Emission-Computed, Single-Photon
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