Diclofenac sodium and prednisolone acetate ophthalmic solution in controlling inflammation after cataract surgery.

Abstract

Cataract is the leading cause of blindness throughout the world. This prospective study was conducted in the department of ophthalmology, Mymensingh Medical college Hospital. Patients of both sexes of 45 to 70 years of age range admitted for cataract surgery were selected for this study. Patients were randomly selected during the period June 2007 to December 2008 with age related cataract. Total 80 patients were included in the study dividing into two groups. In Group-A, 40 patients were treated with diclofenac sodium 0.1% eye drop -1 drop 4 times daily for 30 days after cataract surgery. In Group-B 40 patients were treated with prednisolone acetate 1% eye drop-1 drop-2 hourly 1 week, 1 drop 4 hourly for 2 weeks than 1 drop 6 hourly for 30 days after cataract surgery. Male were 70% and female were 30% in both groups A & B. Post operative inflammation were evaluated by slit lamp examination of cells, flares & keratic precipitate (KP). Patients were evaluated on 1st, 7th and 30th postoperative day. Anterior chamber cells were found 10% in grade-I, 45% in grade-II, 45% in grade-III of group-A and 15% in grade-I, 40% in grade-II, 45% in grade-III patients of group-B in 1st visit. Anterior chamber cells reduce in 2nd visit & in final visit anterior chamber cells were absent in 90% patients in group-A & 92.5% patients in group-B. Anterior chamber flares were found in 32.5% in grade-I, 42.5% in grade-II, 25% patients in grade-III of group-A & 32.5% in grade-I, 47.5% in grade-II, 20% in grade-III of group-B in 1st visit. Anterior chamber flares reduce in both groups in 2nd visit. In final visit anterior chamber flares absent 90% patients in group-A & 90% patients in group-B. KP were found 17.5% patients in grade-I of group-A & 20% patients in grade-I of group-B. In 2nd visit KP reduced in both groups & in final visit KP were absent in 95% patients of group-A & 95% patients of group-B. Analysis shows no significant difference in cells, flares and KP in both groups. Visual acuity with pin hole at final visit- in group-A 5% had 6/18, 10% had 6/12, 50% had 6/9, 35% had 6/6 and in group-B 5% had 6/18, 5% had 6/12, 57.5% had 6/9 and 32.5% had 6/6. Visual outcome were good in both the groups. No statistical significant difference was found between two groups. At each visit there was no statistically significant difference of post operative inflammation between two groups of patients.

• Authors: M M Hossain, A A Mohiuddin, M A Hossain, M A Aziz
• Journal: Mymensingh medical journal : MMJ (Mymensingh Med J) Vol. 19 Issue 3 Pg. 343-7 (Jul 2010) ISSN: 1022-4742 [Print] Bangladesh
• PMID: 20639824 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Anti-Inflammatory Agents
• Cyclooxygenase Inhibitors
• Ophthalmic Solutions
• Diclofenac
• prednisolone acetate
• Prednisolone

Topics

• Aged
• Anti-Inflammatory Agents (pharmacology, therapeutic use)
• Cataract Extraction (adverse effects)
• Cyclooxygenase Inhibitors (pharmacology, therapeutic use)
• Diclofenac (pharmacology, therapeutic use)
• Female
• Humans
• Male
• Middle Aged
• Ophthalmic Solutions
• Prednisolone (analogs & derivatives, pharmacology, therapeutic use)
• Prospective Studies
• Uveitis, Anterior (etiology, prevention & control)
• Visual Acuity (drug effects)