Protective effects of selenium, calcium, and magnesium against arsenic-induced oxidative stress in male rats.

Abstract

Inorganic arsenic is a potent carcinogen and environmental pollutant. More than one hundred million people are reported to be exposed to elevated concentrations of arsenic mainly via drinking water. Essential trace elements can affect toxicity of metals by interacting with metals at the primary site of action and can also modify the body's response to toxic metals by altering their metabolism and transport. This study investigates the effects of concomitant administration of selenium, magnesium, and calcium with arsenic on blood biochemistry and oxidative stress. Selenium was the most effective in reducing arsenic-induced inhibition of blood delta-aminolevulinic acid dehydratase (ALAD) activity and liver oxidative stress. Calcium and magnesium also showed favourable effects on haematological and other biochemical parameters. Because selenium was the most effective, it should be added to chelation therapy to achieve the best protective effects against arsenic poisoning in humans.

• Authors: Deepti Srivastava, Ramlingam B Subramanian, Datta Madamwar, Swaran J S Flora
• Journal: Arhiv za higijenu rada i toksikologiju (Arh Hig Rada Toksikol) Vol. 61 Issue 2 Pg. 153-9 (Jun 2010) ISSN: 1848-6312 [Electronic] Croatia
• PMID: 20587388 (Publication Type: Journal Article)

Chemical References

• Reactive Oxygen Species
• Thiobarbituric Acid Reactive Substances
• Porphobilinogen Synthase
• Glutathione
• Selenium
• Magnesium
• Arsenic
• Calcium

Topics

• Animals
• Arsenic (toxicity)
• Calcium (pharmacology)
• Glutathione (blood)
• Kidney (metabolism)
• Liver (metabolism)
• Magnesium (pharmacology)
• Male
• Oxidative Stress (drug effects)
• Porphobilinogen Synthase (blood)
• Rats
• Rats, Wistar
• Reactive Oxygen Species (metabolism)
• Selenium (pharmacology)
• Thiobarbituric Acid Reactive Substances (metabolism)