Abstract | OBJECTIVE: METHODS: The NNQ is the number of patients one has to treat in order to gain 1 QALY. It is calculated as the inverted value of the utility gain (area under the curve) over 1 year in a cohort subjected to an intervention. EuroQol Index utility data from the South Swedish Arthritis Treatment register were used. RESULTS: Patients with RA (n = 1,001), PsA (n = 241), and SpA (n = 255) were eligible for the study. First, second, and third treatment courses were studied. For RA, NNQ was 4.5, 6.4, and 5.2 for first, second, and third courses, respectively. For PsA and SpA, NNQ was 4.2-4.5, irrespective of treatment order. Treatment groups with <50 patients were not analyzed. During the study period 2002-2007, there were no secular trends of utility gains. CONCLUSION: The NNQ is an easily derived and understandable utility-based outcome measure that may be useful for stakeholders and decision makers as well as for clinicians. It was readily applied in this study of TNF blockade across 3 arthritis diagnoses. NNQ varied little over diagnoses and treatment course order, with a possible exception in second treatment course in RA.
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Authors | Anders Gülfe, Lars Erik Kristensen, Tore Saxne, Lennart T H Jacobsson, Ingemar F Petersson, Pierre Geborek |
Journal | Arthritis care & research
(Arthritis Care Res (Hoboken))
Vol. 62
Issue 10
Pg. 1399-406
(Oct 2010)
ISSN: 2151-4658 [Electronic] United States |
PMID | 20506121
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antirheumatic Agents
- Biological Products
- Tumor Necrosis Factor-alpha
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Topics |
- Adult
- Antirheumatic Agents
(pharmacology, therapeutic use)
- Arthritis, Psoriatic
(drug therapy, epidemiology, pathology)
- Arthritis, Rheumatoid
(drug therapy, epidemiology, pathology)
- Biological Products
(therapeutic use)
- Cohort Studies
- Female
- Humans
- Male
- Middle Aged
- Outcome Assessment, Health Care
(standards)
- Quality-Adjusted Life Years
- Spondylarthritis
(drug therapy, epidemiology, pathology)
- Sweden
(epidemiology)
- Treatment Outcome
- Tumor Necrosis Factor-alpha
(antagonists & inhibitors, physiology)
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