[The efficacy of cholestyramine as a hypocholesterolemic agent and its tolerance in a Mexican population].

Abstract

The tolerance and efficacy of cholestyramine (12-16 gr/day) was evaluated in 19 patients with primary type-IIa hyperlipoproteinemia. All patients were on an isocaloric low-cholesterol diet that began at least one month before entry, and was continued during the eight weeks of the study. Cholestyramine significantly (p less than 0.001) lowered the plasma levels of cholesterol and of low density lipoprotein cholesterol from means of 288 +/- 46 mg/dl to 244 +/- 44 mg/dl and from 221 +/- 50 mg/dl to 171 +/- 46 mg/dl respectively. These were reductions of 15 and 22%. The magnitude of response to cholestyramine was unrelated to age, sex, cause of the hypercholesterolemia (familial or polygenic) or basal cholesterol levels. The drug was well tolerated. Only one patient was excluded because gastrointestinal discomfort. Because of its safety and efficacy, cholestyramine can be recommended as a first choice drug in the treatment of hypercholesterolemia.

• Authors: I Lerman Garber, G Cardoso Saldaña, J Zamora González, M Ahumada Ayala, E García Rubí, C Posadas Romero
• Journal: Archivos del Instituto de Cardiologia de Mexico (Arch Inst Cardiol Mex) 1991 Jan-Feb Vol. 61 Issue 1 Pg. 47-51 ISSN: 0020-3785 [Print] Mexico
• Vernacular Title: Eficacia como agente hipocolesterolemiante y tolerancia de la colestiramina en población mexicana.
• PMID: 2048910 (Publication Type: English Abstract, Journal Article)

Chemical References

• Cholesterol, Dietary
• Lipids
• Lipoproteins
• Cholestyramine Resin

Topics

• Adult
• Aged
• Cholesterol, Dietary (administration & dosage)
• Cholestyramine Resin (adverse effects, therapeutic use)
• Diet, Reducing
• Drug Evaluation
• Drug Tolerance
• Humans
• Hypercholesterolemia (blood, drug therapy)
• Lipids (blood)
• Lipoproteins (blood)
• Mexico
• Middle Aged