Abstract | BACKGROUND: METHODS: A retrospective review at a tertiary children's hospital (July 2003 to August 2008) identified 6 infants with intestinal failure requiring PN for >6 months who developed severe hepatic dysfunction that was managed by eliminating SLE and providing enteral fish oil. RESULTS: Twenty-three infants with short bowel syndrome requiring prolonged PN developed cholestasis. SLE was removed in 6 of these patients, and 4 of the 6 received enteral fish oil. Standard PN included 2-3 g/kg/d SLE with total PN calories ranging from 57 to 81 kcal/kg/ d at the time of SLE removal. Hyperbilirubinemia resolved after elimination of SLE within 1.8-5.4 months. Total PN calories required to maintain growth generally did not change. CONCLUSIONS: Temporary elimination of SLE and supplementation with enteral fish oil improved cholestasis in PN-dependent infants. Further trials are needed to evaluate this management strategy.
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Authors | Michael D Rollins, Eric R Scaife, W Daniel Jackson, Rebecka L Meyers, Cecilia W Mulroy, Linda S Book |
Journal | Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition
(Nutr Clin Pract)
Vol. 25
Issue 2
Pg. 199-204
(Apr 2010)
ISSN: 1941-2452 [Electronic] United States |
PMID | 20413701
(Publication Type: Journal Article)
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Chemical References |
- Fat Emulsions, Intravenous
- Fish Oils
- Soybean Oil
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Topics |
- Cholestasis
(etiology, therapy)
- Enteral Nutrition
- Fat Emulsions, Intravenous
(adverse effects, chemistry, therapeutic use)
- Fish Oils
(adverse effects, therapeutic use)
- Humans
- Infant
- Infant, Newborn
- Parenteral Nutrition
(adverse effects, methods)
- Retrospective Studies
- Short Bowel Syndrome
(complications, therapy)
- Soybean Oil
(adverse effects)
- Soybeans
- Survival Rate
- Treatment Outcome
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