Aortic Customize: an in vivo feasibility study of a percutaneous technique for the repair of aortic aneurysms using injectable elastomer.

Abstract

OBJECTIVE:

This study aimed to test a percutaneous technique for aneurysm-sac filling by means of in situ polymerisation in an in vivo model.

DESIGN:

Aortic Customize is a new endovascular treatment concept for aortic aneurysms: a non-cross-linked liquid elastomer is injected to fill the aneurysm sac around a balloon-catheter. With this method, a compliant elastomer mould with a patent lumen is created.

MATERIAL:

The formulation used in the experiments consisted of a two-component addition-cure liquid-silicone formulation, based on vinyl-terminated polydimethylsiloxane (PDMS).

METHODS:

The concept of aneurysm-sac filling was tested in vivo in porcine experiments (n = 3).

RESULTS:

In vivo porcine experiments with the sac-filling application showed successful exclusion of the created aneurysms with patent lumens and absence of endoleaks. The aneurysms were excluded successfully in the in vivo model, injecting elastomer through a 7-French catheter, filling up the entire aneurysm sac.

CONCLUSIONS:

These in vivo experiments demonstrate that the principle of aneurysm-sac filling by means of in situ curing is feasible, excluding the aneurysm and creating a new lumen. Further long-term animal experiments must be done prior to consideration of clinical application.

• Authors: W M P F Bosman, J Vlot, T J van der Steenhoven, O van den Berg, J F Hamming, A C de Vries, H L F Brom, M J Jacobs
• Journal: European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery (Eur J Vasc Endovasc Surg) Vol. 40 Issue 1 Pg. 65-70 (Jul 2010) ISSN: 1532-2165 [Electronic] England
• PMID: 20382549 (Publication Type: Journal Article)
• Copyright: Copyright 2010 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.

Chemical References

• Dimethylpolysiloxanes
• Silicone Elastomers

Topics

• Animals
• Aortic Aneurysm, Abdominal (diagnostic imaging, therapy)
• Aortography
• Blood Vessel Prosthesis
• Blood Vessel Prosthesis Implantation (instrumentation, methods)
• Catheterization
• Dimethylpolysiloxanes (administration & dosage)
• Disease Models, Animal
• Feasibility Studies
• Injections, Intralesional
• Prosthesis Design
• Silicone Elastomers (administration & dosage)
• Swine