[Experimental cutaneous sporotrichosis: in vivo evaluation of itraconazole and terbinafine].
|
| Abstract |
The aim of this study was to evaluate the in vivo activity of itraconazole and terbinafine for treating experimental cutaneous sporotrichosis. Eighty Wistar rats were used, divided into four groups (TERB20, TERB30, ITRA and CONT). They were inoculated in the left plantar pad with 0.2 ml of solution containing 2x10(3) cell/ml of Sporothrix schenckii and treated with terbinafine (20 and 30 mg/kg), itraconazole (10 mg/kg) or placebo for 13 weeks. The lesions at the inoculation site were evaluated and measured weekly, along with their dissemination. Mycological and histopathological analyses were performed subsequently. The results showed that the animals in the ITRA group differed statistically in all parameters evaluated, in relation to CONT. For terbinafine, there were no statistical differences between the treated and control groups. It could be confirmed that itraconazole presented good activity for treating sporotrichosis, while terbinafine was ineffective for this disease at the doses used. However, more studies on the latter antifungal agent are needed.
|
|---|---|
| Authors | Tatiana de Avila Antunes, Márcia de Oliveira Nobre, Renata Osório de Faria, Ana Raquel Mano Meinerz, Anelise Afonso Martins, Marlete Brum Cleff, Cristina Gevehr Fernandes, Mário Carlos Araújo Meireles |
| Journal | Revista da Sociedade Brasileira de Medicina Tropical (Rev Soc Bras Med Trop) 2009 Nov-Dec Vol. 42 Issue 6 Pg. 706-10 ISSN: 1678-9849 [Electronic] Brazil |
| Vernacular Title | Esporotricose cutânea experimental: Avaliação in vivo do itraconazol e terbinafina. |
| PMID | 20209359 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
| Chemical References |
|
| Topics |
|
Join CureHunter, for free Research Interface BASIC access!
Realize the full power of the drug-disease research graph!