Abstract | BACKGROUND: HYPOTHESIS: METHODS: Patients with preserved left ventricular ejection fraction (> or =50%), hospitalized for clinical symptoms of heart failure were evaluated. Patients on statin therapy started at or prior to their first heart failure admission represented group 1 and patients without statin therapy represented group 2. The effects of statins on hospitalization rates and mortality were assessed during a 5 year follow-up. RESULTS: A total of 270 patients (group 1 n = 81; group 2 n = 189) were followed over 5 years. Patients on statins demonstrated improved survival compared to patients without statin therapy (hazard ratio [HR] = 0.65, 95% confidence interval [CI]: 0.45-0.95, P = .029). The survival benefit was maintained after adjusting for differences in baseline characteristics, comorbidities, and other medications. There was no significant difference in the mean cardiovascular hospitalization rate (3.0 +/- 3.2 vs 3.8 +/- 4.7, P = .23) and in overall hospitalization rate (7.1 +/- 6.3 vs 7.8 +/- 7.7, P = .52) between groups 1 and 2, respectively. CONCLUSION:
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Authors | Faramarz Tehrani, Ryan Morrissey, Anita Phan, Christopher Chien, Ernst R Schwarz |
Journal | Clinical cardiology
(Clin Cardiol)
Vol. 33
Issue 4
Pg. E1-5
(Apr 2010)
ISSN: 1932-8737 [Electronic] United States |
PMID | 20127896
(Publication Type: Journal Article)
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Copyright | Copyright 2009 Wiley Periodicals, Inc. |
Chemical References |
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
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Topics |
- Aged
- Aged, 80 and over
- Female
- Heart Failure, Diastolic
(drug therapy, mortality, physiopathology)
- Hospital Mortality
- Hospitalization
(statistics & numerical data)
- Humans
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
(therapeutic use)
- Male
- Proportional Hazards Models
- Statistics, Nonparametric
- Survival Rate
- Treatment Outcome
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