Abstract | BACKGROUND AND AIM: MATERIALS AND METHODS: RESULTS: Such feeding significantly increased createnine, bilirubin, urea nitrogen, alkaline phosphatase and transaminases concentrations. The immunological results showed a significant decrease in lymphocytes of the total white blood cells, immunoglobulin profile (Ig G and Ig A), T-cells sub-types (CD3(+), CD4(+) and CD8(+)), NK and pro-inflammatory cytokines ( TNFalpha and IL-1beta) typical of aflatoxicosis. Both HSCAS and TM at the level of 5 g/kg contaminated diet resulted in a significant improvement in all immunological parameters-in lymphocyte, immunoglobulin profile, T-cells sub-types and pro-inflammatory cytokines as well as the mineral status and the biochemical parameters. CONCLUSIONS: The deleterious effects of aflatoxin could be overcome or, at least, diminished by the addition of sorbents. Moreover, both tested sorbents by themselves had no toxic effects and bind aflatoxin with high affinity.
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Authors | Samir Abbès, Jalila Ben Salah-Abbès, Mosaad A Abdel-Wahhab, Ridha Ouslati |
Journal | Immunopharmacology and immunotoxicology
(Immunopharmacol Immunotoxicol)
Vol. 32
Issue 3
Pg. 514-22
(Sep 2010)
ISSN: 1532-2513 [Electronic] England |
PMID | 20088648
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Aflatoxins
- Albumins
- Aluminum Silicates
- Blood Proteins
- Interleukin-1
- Metals, Heavy
- Triglycerides
- Tumor Necrosis Factor-alpha
- Bentonite
- sodium calcium aluminosilicate, hydrated
- Cholesterol
- Creatinine
- Cholinesterases
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Topics |
- Adsorption
- Aflatoxins
(antagonists & inhibitors, immunology, toxicity)
- Albumins
(analysis)
- Aluminum Silicates
(pharmacology)
- Animals
- Bentonite
(pharmacology)
- Blood Proteins
(analysis)
- Blood Urea Nitrogen
- Cholesterol
(blood)
- Cholinesterases
(blood)
- Creatinine
(blood)
- Female
- Interleukin-1
(blood)
- Leukocytes
(drug effects)
- Liver
(drug effects, enzymology)
- Metals, Heavy
(blood)
- Rats
- Triglycerides
(blood)
- Tumor Necrosis Factor-alpha
(blood)
- Tunisia
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