Hyperfunctioning metastatic follicular thyroid carcinoma in Pendred's syndrome.

Abstract

A 66-year-old woman with Pendred's syndrome underwent a partial thyroidectomy when she was 17 years old. At the age of 52 years, she had a second thyroid operation because of hyperthyroidism due to a toxic multinodular goiter with a mediastinal extension consisting of several separate nodules. Five years later a hyperfunctioning metastatic follicular carcinoma was diagnosed histologically. After treatment with radioactive iodine, the patient was well. To the authors' knowledge, this is the first description of a metastatic follicular thyroid carcinoma in Pendred's syndrome and the first report of hyperthyroidism occurring after malignant degeneration of a dyshormonogenetic goiter.

• Authors: R Abs, J Verhelst, E Schoofs, E De Somer
• Journal: Cancer (Cancer) Vol. 67 Issue 8 Pg. 2191-3 (Apr 15 1991) ISSN: 0008-543X [Print] United States
• PMID: 2004339 (Publication Type: Case Reports, Journal Article)

Chemical References

• Iodine Radioisotopes

Topics

• Adenocarcinoma (blood, complications, secondary)
• Aged
• Female
• Goiter (complications, congenital)
• Humans
• Hyperthyroidism (etiology)
• Iodine Radioisotopes (therapeutic use)
• Syndrome
• Thyroid Neoplasms (blood, complications, radiotherapy)