Effect of zindoxifene on experimental prostatic tumours of the rat.

Abstract

The anti-oestrogen zindoxifene was originally developed as a drug for the treatment of hormone-dependent mammary carcinomas. Experiments with rats bearing androgen-dependent prostatic tumours revealed anti-neoplastic activity of zindoxifene on these tumours also. Therefore, the inhibitory effect of this drug was studied in various prostatic tumour models in comparison to the anti-oestrogen tamoxifen and to castration. The growth of the hormone-dependent Dunning R3327 H tumour was strongly inhibited by zindoxifene (4 mg/kg), which was more effective than tamoxifen (43% T/C vs 87% T/C, the ratios of tumour weights in control and drug-treated rats). Zindoxifene was able to delay the relapse of these tumours by 7 weeks in comparison to castration. The experiments with Noble Nb-R prostatic tumours showed that administration of zindoxifene (5 mg) is superior to castration (5% T/C vs 52% T/C). The growth of tumours in castrated rats was completely inhibited by administration of zindoxifene. Therefore a peripheral mode of action has to be assumed.

• Authors: M R Schneider, C D Schiller, A Humm, E von Angerer
• Journal: Journal of cancer research and clinical oncology (J Cancer Res Clin Oncol) Vol. 117 Issue 1 Pg. 33-6 ( 1991) ISSN: 0171-5216 [Print] Germany
• PMID: 1997466 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Estrogen Antagonists
• Indoles
• Tamoxifen
• zindoxifene
• Diethylstilbestrol

Topics

• Adenocarcinoma (drug therapy)
• Animals
• Antineoplastic Agents (pharmacology)
• Castration
• Diethylstilbestrol (pharmacology)
• Estrogen Antagonists (pharmacology)
• Indoles (pharmacology)
• Male
• Neoplasm Transplantation
• Neoplasms, Experimental (drug therapy)
• Neoplasms, Hormone-Dependent (drug therapy)
• Prostatic Neoplasms (drug therapy)
• Rats
• Rats, Inbred F344
• Tamoxifen (pharmacology)