Abstract | INTRODUCTION: Currently available treatments for osteoarthritis (OA) are restricted to nonsteroidal anti-inflammatory drugs, which exhibit numerous side effects and are only temporarily effective. Thus novel, safe and more efficacious anti-inflammatory agents are needed for OA. Naturally occurring polyphenolic compounds, such as curcumin and resveratrol, are potent agents for modulating inflammation. Both compounds mediate their effects by targeting the NF-kappaB signalling pathway. METHODS: We have recently demonstrated that in chondrocytes resveratrol modulates the NF-kappaB pathway by inhibiting the proteasome, while curcumin modulates the activation of NF-kappaB by inhibiting upstream kinases (Akt). However, the combinational effects of these compounds in chondrocytes has not been studied and/or compared with their individual effects. The aim of this study was to investigate the potential synergistic effects of curcumin and resveratrol on IL-1beta-stimulated human chondrocytes in vitro using immunoblotting and electron microscopy. RESULTS: CONCLUSIONS: We propose that combining these natural compounds may be a useful strategy in OA therapy as compared with separate treatment with each individual compound.
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Authors | Constanze Csaki, Ali Mobasheri, Mehdi Shakibaei |
Journal | Arthritis research & therapy
(Arthritis Res Ther)
Vol. 11
Issue 6
Pg. R165
( 2009)
ISSN: 1478-6362 [Electronic] England |
PMID | 19889203
(Publication Type: Journal Article)
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Chemical References |
- Anti-Inflammatory Agents
- Interleukin-1beta
- NF-kappa B
- Stilbenes
- Curcumin
- Resveratrol
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Topics |
- Anti-Inflammatory Agents
(pharmacology)
- Apoptosis
(drug effects)
- Blotting, Western
- Cell Proliferation
(drug effects)
- Cells, Cultured
- Chondrocytes
(drug effects, metabolism, ultrastructure)
- Curcumin
(pharmacology)
- Drug Synergism
- Humans
- Inflammation
(immunology, metabolism)
- Interleukin-1beta
(drug effects)
- Microscopy, Electron, Transmission
- NF-kappa B
(drug effects)
- Resveratrol
- Signal Transduction
(drug effects)
- Stilbenes
(pharmacology)
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