Role of lipoxygenases and lipoxin A(4)/annexin-1 receptor in gastric protection induced by 20% ethanol or sodium salicylate in rats.

Abstract

The role of cyclooxygenases and prostaglandins in experimental models of gastroprotection is well established. We investigated the effects of the 5-lipoxygenase inhibitor A63162, the 12-lipoxygenase inhibitor baicalein and the 15-lipoxygenase inhibitor PD146176 as well as the nonspecific lipoxin A(4)/annexin-1 antagonist Boc1 on adaptive protection induced by 20% ethanol against 70% ethanol, and on protection induced by sodium salicylate against the mucosal-damage-aggravating effects of celecoxib and dexamethasone during local ischemia-reperfusion in rats. It was found that both types of gastroprotection were antagonized by the lipoxygenase inhibitors and the lipoxin A(4)/annexin-1 antagonist in doses that have no direct damaging effect on gastric mucosa. The results suggest that not only cyclooxygenases, but also active lipoxygenases and, possibly, annexin-1 are required for these types of gastroprotection to occur.

• Authors: Brigitta M Peskar, Karlheinz Ehrlich, Rufina Schuligoi, Bernhard A Peskar
• Journal: Pharmacology (Pharmacology) Vol. 84 Issue 5 Pg. 310-3 ( 2009) ISSN: 1423-0313 [Electronic] Switzerland
• PMID: 19844131 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright 2009 S. Karger AG, Basel.

Chemical References

• 6,11-dihydro-5-thia-11-aza-benzo(a)-fluorene
• Acetamides
• Annexins
• Cyclooxygenase 2 Inhibitors
• Cyclooxygenase Inhibitors
• Flavanones
• Fluorenes
• Glucocorticoids
• Lipoxygenase Inhibitors
• Oligopeptides
• Phenyl Ethers
• Prostaglandin Antagonists
• Pyrazoles
• Receptors, Formyl Peptide
• Receptors, Lipoxin
• Sulfonamides
• lipoxin A(4) receptor, rat
• N-hydroxy-N-(1-(4-(phenylmethoxy)phenyl)ethyl)-acetamide
• Ethanol
• baicalein
• t-butyloxycarbonyl-methionyl-leucyl-phenylalanine
• Dexamethasone
• Lipoxygenase
• Celecoxib
• Sodium Salicylate

Topics

• Acetamides (pharmacology)
• Animals
• Annexins (metabolism)
• Celecoxib
• Cyclooxygenase 2 Inhibitors (pharmacology)
• Cyclooxygenase Inhibitors (pharmacology)
• Dexamethasone (pharmacology)
• Drug Interactions
• Ethanol (pharmacology)
• Flavanones (pharmacology)
• Fluorenes (pharmacology)
• Gastric Mucosa (blood supply, drug effects, pathology)
• Glucocorticoids (pharmacology)
• Lipoxygenase (physiology)
• Lipoxygenase Inhibitors (pharmacology)
• Male
• Oligopeptides (pharmacology)
• Phenyl Ethers
• Prostaglandin Antagonists (pharmacology)
• Pyrazoles (pharmacology)
• Rats
• Rats, Wistar
• Receptors, Formyl Peptide (physiology)
• Receptors, Lipoxin (antagonists & inhibitors)
• Reperfusion Injury (metabolism, pathology, prevention & control)
• Sodium Salicylate (pharmacology)
• Sulfonamides (pharmacology)