Application of the margin of exposure (MoE) approach to substances in food that are genotoxic and carcinogenic - example: 1-methylcyclopropene and its impurities (1-chloro-2-methylpropene and 3-chloro-2-methylpropene).

Abstract

The chlorinated impurities of 1-methylcyclopropene possess weak mutagenicity and are carcinogenic in rodent bioassays. Dose-response modelling of the data for 1-chloro-2-methylpropene gave a BMDL10 for nasal carcinomas in male rats of 11 mg/kg-bw/day (after correction for the 5 days/week dosage schedule). No human exposure data are available and theoretical estimates had to be used to calculate the MoE. The MoEs ranged from 40,000 to 100,000,000 depending on the assumptions used in the exposure estimation.

• Authors: Andrew Renwick, Jean-Charles Leblanc, R Woodrow Setzer
• Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association (Food Chem Toxicol) Vol. 48 Suppl 1 Pg. S81-8 (Jan 2010) ISSN: 1873-6351 [Electronic] England
• PMID: 19786060 (Publication Type: Journal Article, Review)
• Copyright: Copyright 2009 ILSI Europe. Published by Elsevier Ltd.. All rights reserved.

Chemical References

• Allyl Compounds
• Carcinogens
• Cyclopropanes
• Mutagens
• Plant Growth Regulators
• 1-chloro-2-methylpropene
• 3-chloro-2-methylprop-1-ene
• 1-methylcyclopropene
• Vinyl Chloride

Topics

• Allyl Compounds (toxicity)
• Animals
• Carcinogens (toxicity)
• Cyclopropanes (toxicity)
• Data Interpretation, Statistical
• Diet
• Female
• Food Contamination (analysis)
• Humans
• Male
• Mice
• Models, Statistical
• Mutagens (toxicity)
• Plant Growth Regulators (toxicity)
• Rats
• Vinyl Chloride (analogs & derivatives, toxicity)