Abstract | AIM: METHODS: Thirty-two patients with nephrotic syndrome and biopsy-proven iMGN were included in the study. At presentation, 9 patients were found to be in stage 1, 13 patients in stage 2 and 10 patients in stage 3 chronic kidney disease. In all patients, i.v. methylprednisolone pulses (500 mg/day for 3 days) were administered, followed by oral prednisone at an initial dose of 1 mg/kg per day, tapered gradually after 8 weeks to the maintenance dose of 5 mg/day after 6 months, and chlorambucil 2 mg twice daily for 6 months. RESULTS: Complete remission of nephrotic syndrome was obtained in 14 patients (47.3%) and partial remission in 16 patients (50%). Two patients relapsed after 1 year of treatment. We did not record any severe side effects in treated patients, except glucose intolerance in 4 subjects on high corticosteroid doses. CONCLUSION: Immunosuppressive treatment with corticosteroids and low-dose chlorambucil seems to be effective and well tolerated in nephrotic patients with iMGN.
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Authors | Ilona Idasiak-Piechocka, Andrzej Oko, Katarzyna Łochyńska-Bielecka, Beata Skrobańska |
Journal | Kidney & blood pressure research
(Kidney Blood Press Res)
Vol. 32
Issue 4
Pg. 263-7
( 2009)
ISSN: 1423-0143 [Electronic] Switzerland |
PMID | 19776643
(Publication Type: Clinical Trial, Journal Article)
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Copyright | (c) 2009 S. Karger AG, Basel. |
Chemical References |
- Anti-Inflammatory Agents
- Antineoplastic Agents, Alkylating
- Serum Albumin
- Chlorambucil
- Prednisone
- Methylprednisolone
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Topics |
- Adult
- Anti-Inflammatory Agents
(therapeutic use)
- Antineoplastic Agents, Alkylating
(administration & dosage, adverse effects, therapeutic use)
- Chlorambucil
(administration & dosage, adverse effects, therapeutic use)
- Female
- Follow-Up Studies
- Glomerulonephritis, Membranous
(complications, drug therapy, pathology)
- Humans
- Kidney Failure, Chronic
(complications, pathology)
- Male
- Methylprednisolone
(therapeutic use)
- Middle Aged
- Nephrotic Syndrome
(complications, drug therapy, pathology)
- Prednisone
(therapeutic use)
- Proteinuria
(drug therapy)
- Serum Albumin
(metabolism)
- Treatment Outcome
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